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Nov 13, 2024 — We report results from a randomized phase 2 DEEPER trial (UMIN000018217, jRCTs061180022) to test the superiority of modified (m)-FOLFOXIRI plus **by M Shiozawa · 2024 · Cited by 13 — We report results from a randomized phase 2 DEEPER trial (UMIN000018217, jRCTs061180022) to test the superiority of modified (m)-FOLFOXIRI #by A Tsuji · 2025 · Cited by 1 — The final survival analysis of the DEEPER trial demonstrated favorable PFS and OS with m-FOLFOXIRI plus cet in pts with RAS/BRAF wild-type and @We therefore performed a randomized phase II study, DEEPER trial (JACCRO CC-13) NCT02515734, to investigate the efficacy and safety of cetuximab (cet) vs.&Jan 25, 2025 — Initial treatment with cetuximab yields better outcomes than bevacizumab when combined with mFOLFOXIRI in select patients with mCRC./In this trial, the researchers want to learn how well BAY2927088 (sevabertinib) works in people with different types of solid tumors with HER2 mutations. These *|Therefore, we investigated the efficacy and safety of bev vs. cet in combination with FOLFOXIRI in previously untreated mCRC patients with RAS wild-type tumors.